Hypofibrinogenemia caused by tigecycline use in a patient with acute cholecystitis: a case report and review of the literature

Tigecycline is the first member of glicylcycline class antibiotics, which has a broad spectrum action. In previous reports, coagulopathy and hypofibrinogenemia caused by tigecycline use was described. We aimed to present case in association with use. A 79-years-old male admitted medical intensive care unit for acute cholecystitis renal failure. He had no history coagulation disorder. receiving meropenem septic shock on admission. On 7th day meropenem, his infection didn’t improve fever continued. Because that added treatment. Patient’s parameters improved, dropped under treatment, but prothrombin time, international normalized ratio activated partial thromboplastin time levels increased fibrinogen level decreased (0.96 g/L). discontinued day. fifth after cessasion tigecycline, other returned normal ranges. The mechanisms should be elucidated futher studies. strictly suggest, regular monitoring patients